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GENE OVER EXORESSION MUST BE ADDRESSED

Most of you have seen various therapies for Down syndrome on the internet. However, Targeted Nutritional Intervention (TNI) is the only one that uses a sound, studied, scientific approach to the effective treatment of DS. In Down syndrome, the delicate balance of proteins, enzymes and hormones is disrupted at the cell level. It is an issue of chaotic biochemistry.. Down syndrome is a progressive, neurodegenerative disease that can only be effectively addressed at the cellular level. Although physical, occupational, speech and neuro developmental therapies are clearly beneficial, because the active genes, if left to themselves, continue to damage the brain, their positive effects are temporary at best.

One “non” TNI therapy is centered around the selective serotonin reuptake inhibitor, Prozac, Prozac may provide some benefit for Down syndrome. A study on the DS mouse model resulted in improvement to the structure of the brain of exposed pups.  1.)  However, to date there is no clinical evidence that such physical alterations can be achieved after the developmental stage in the womb. However, there is evidence that Prozac encourages neurogenesis (the development of new neurons in the hippocampus). Unfortunately many of the excess proteins and enzymes in Down syndrome actually destroy new neurons or prevent them from properly forming and migrating throughout the brain. Unless you also address them, your child will not enjoy long term benefits. Prozac can be used in addition to Targeted Nutritional Intervention. TNI reduces the levels of harmful gene products preventing the inhibition of the creation of neurons. Fortunately, Prozac is not the only option for neurogenesis. Lithium Oritate, a mineral, and several plant polyphenols also encourage the development of neurons with no prescription required and no potential side effects.

Prozac is presently being studied in human mothers expecting babies who will be born with Down syndrome.  2.) Still, Prozac is not a cure even if it can indeed alter the structure of the developing brain.  The Down syndrome mouse model is critical for DS research, however, the mice have more than 700 additional proteins than human beings in addition to the genome that makes them mice. Not everything that works in the mouse model will be effective in people. Predictors of whether or not a substance studied in mice will provide the same benefit in Down syndrome are studies in “non” DS individuals that achieve similar results. Unfortunately studies of Prozac during normal pregnancies have resulted in deficits of oxygen and nutrients supplied to the developing fetus. 3.) Thus, this predictor does not bode well for a successful outcome in human infants. In the event the trial is successful, the child’s cells will still contain excess active genes. So long as these genes are not down regulated or the additional genetic material removed from every cell in the body, they will continue on their path of destruction.

One practitioner claims that TNI is “one size fits all” when nothing could be further from the truth. The rationale of Targeted Nutritional Intervention is not complicated. Your child has multiple over expressed genes. The excess proteins and enzymes produced by those genes are directly responsible every single issue associated with Down syndrome, even hypothyroidism. Failing to down regulate these genes is like throwing a tarp over a a smoldering fire, covering it but allowing it to burn. Out of sight, out of mind, right? Wrong. Just as fire will ultimately destroy the tarp so will these genes destroy everything else you attempt to do to help your child.

supplementing to make your child’s blood or urine conform to a “normal” profile cannot alter your child’s genome. Taking a multi vitamin product that is not specific to DS may actually be harmful and repeated studies on multi vitamins demonstrate no benefit. However, trials on Nutrivene resulted in measurable, and scientifically significant improvements in verbally health, growth, strength, gross and fine motor skills and child gnitve function. So what’s the difference?  They’re  only vitamins, right? Wrong. Nutrivene was formulated by a team of scientists to manipulate genes and proteins. Some nutrients directly target a gene at the point of transcription. Others are necessary co factors but all work in perfect synergy to address the excess proteins that are destroying your child’s body and mind. Each gene has been studied to determine its natural inhibitor or suppressor. Critical proteins, neurotransmitters, and biochemical pathways are carefully addressed. Each active ingredient has been through trials and the results published in peer reviewed journals attesting to its ability to manipulate genes. If you do not address gene over expression, anything else you do will be of little lasting value as the genes that are responsible for your child’s challenges are left to continue disrupting your children’s biochemistry and rbbing them of an independent future.

The active genes on the Down syndrome critical region of chromosome 21 are constantly creating havoc, killing cells through oxidative stress, blocking the transmission of signals from neuron to neuron, shortening telomeres and in doing so, shortening theIr lives. They disrupt the immune system, damage your child’s vision and hearng, subjecting them to autoimmune diseases, progressive cognitive decline, Leukemia and Alzheimer’s disease. These genes do not just effect their own proteins, they disrupt and destroy the function of the entire genome.

A good example is the disruption of MECP2, a critical protein involved in multiple functions of the brain such as auditory processing, hearing, the development of neurons and dendrites and ultimately it plays a role in normal speech. Yet the gene for this protein is mapped to the X chromosome. This gene is regulated by MicroRNA-155 which is mapped to chromosome 21 and is active and over expressed. This results in low levels of MECP2 hindering many functions of the brain including auditory processing, neuron viability and down the line, it contributes to speech impediments. You simply cannot ignore it. MicroRNA-155 is directly linked to autoimmune diseases, permeable blood brain barrier and leukemia. It is dangerous to allow this microRNA to remain elevated when science has provided a way to down regulate it. Does this mean your child will not develop an autoimmune disease or leukemia? We hope that it does but there are never any guarantees in life and much about DS is yet to be discovered. However, research is very clear that down regulation is indeed possible. Why not at least try? See research under Resveratrol.

The basis of a lasting, effective therapy is a common sense approach. Since it gene over expression that results in an aberrant biochemistry and neurology in Down Syndrome, a therapy that addresses these genes and proteins is more likely to succeed.

Your child needs TNI. It is the most comprehensive therapy available and the only one constantly monitored by scientists for potential improvement based on continuing research. Your children do not simply need supplements, they need supplements that will help normalize their biochemistry.

Let’s look at just one gene, as an example. Some biomedical and naturopathic practitioners suggest supplements or drugs (Prozac) that may trigger neurogenesis. This is the creation of new neurons in the hippocampus of the brain. But, if you do not address the genes and proteins that destroy these new neurons you are wasting both your time and money.

1. PROZAC IN DS MOUSE MODEL

2. PROZAC TRIAL ON HUMAN PREGNANCIES

3SIDE EFFECTS OF PROZAC IN DEVELOPING HUMAN FETUS

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* L RCAN1

contributes to immune dysfunction

And inhibits memory and learning  and so many other serious issue too numerous to mention here though there are many studies regarding this gene on the Research page.

Our protocol addresses this problem in two ways. We down regulate DYRK1a which negatively impacts RCAN1 by using EGCG and we upregulated CREB with PQQ which in turn, down regulates RCAN1.

Using Prozac, EGCG or Lithium Orotate to promote neurogenesis cannot possibly have a lasting benefit unless you control this, and other genes, that destroy neurons. We will look at other genes over the next few weeks.