“One of the most challenging questions in neuroscience is to dissect how learning and memory, the foundational pillars of cognition, are grounded in stable, yet plastic, gene expression states. All known epigenetic mechanisms such as DNA methylation and hydroxymethylation, histone modifications, chromatin remodelling, and noncoding RNAs regulate brain gene expression, both during neurodevelopment and in the adult brain in processes related to cognition. On the other hand, alterations in the various components of the epigenetic machinery have been linked to well-known causes of intellectual disability disorders (IDDs). Two examples are Down Syndrome (DS) and Fragile X Syndrome (FXS), where global and local epigenetic alterations lead to impairments in synaptic plasticity, memory, and learning. Since epigenetic modifications are reversible, it is theoretically possible to use epigenetic drugs as cognitive enhancers for the treatment of IDDs. Epigenetic treatments act in a context specific manner, targeting specific regions and state specific chromatin accessibility, FACILITATING THE ESTABLISHMENT OF “LOST” BALANCE.”

The following full text article speaks mostly of drugs, however, it also discusses the ability of EGCG in DS to down regulate DYRK1a. This study could have been done substituting elements of TNI, such as Curcumin, Resveratrol, PQQ, the nutrients provided in the Daytime and NightTime formula, etc. The point is, the ability to manipulate gene over expression in DS is recognized as not just theoretical but completely possible.

Drug therapies can focus only on one gene at a time due to the restrictive nature of pharmaceuticals and dangerous interactions with each other. A single target protocol will never produce hoped for results. Recently, a study on a GABA antagonist was halted for young children with Down syndrome because there were no lasting benefits shown in adults. I didn’t expect this drug to work, not because it wasn’t effective, but because so much more than simply GABA imbalance is wrong with the neuro biochemistry in the Down syndrome brain. You cannot expect a single thing to provide continuing benefits when so many other proteins are countering the hoped for results.

Here then, is the beauty of TNI. Nature has designed its own pharmaceuticals to work in synergy with each other. By this I mean that the ingredients in this protocol work to support each other and even to enhance the performance of the other ingredients. We can go after the major genes that are over expressed at the same time, with no fear of drug interaction or deadly side effects. Why then, if these exist today and have been proven by research to actually work, would you choose to wait years for a drug that will effect a single gene and have no promise of long lasting results?

You cannot use just anything in nature because many natural products do the opposite to neuro biochemistry in DS than it would in a typical brain. For instance, many products on the market are known antioxidants. It’s a fact that people with DS suffer from oxidative stress. So why not just grab every single natural antioxidant and give it to them? Big mistake. In every cell there is an antioxidant triad of enzymes that function together to change hydrogen peroxide into water and oxygen for the cells usage. But, many of these products, or combination products, work by upregulating the genes in this triad. They have no true antioxidant properties of their own. In DS, the gene for one part of this enzyme triad, Superoxide Dismutase 1 (SOD1) is over expressed. The balance is so disrupted that it simply doesn’t function. Without this enzyme triad functioning your child’s cells have a very short life. This leads to cognitive decline and paves the way for Alzheimer’s disease and premature death. So you must be extremely careful what you give your child because what is beneficial for typical people can be dangerous for people with Down syndrome.

While it is not possible to down regulate SOD1 Nutrivene Daytime formula does something no other product on the market does, it upregulates the other two triad enzymes, Catalase and Glutathione Peroxidase to restore the balance of the antioxidant enzyme system. This was proven in the Miguid study on Nutrivene published in 2001. In that study, SOD1 was NOT effected by the protocol but Catalase and Glutathione Peroxidase were significantly elevated.

In this case we utilized nutrients to directly target Catalase and Glutathione Peroxidase to instruct the genes to create more of those enzymes. While, at the same time, we deliberately avoided anything that would effect SOD1. The result was a minor miracle, the partial restoration of the antioxidant triad in DS. (See Magid Study http://trisomy21research.org/2017/09/19/the-miguid-study-on-nutrivene/). This had never been done before and only Nutrivene can and does do this today.

Since the Miguid Study, Trisomy 21 Research’s scientists have gone after numerous other over expressed genes, disrupted neurotransmitters and disfunctioning biochemical pathways. The results, thus far, have been astonishing. In the future we will continue to manipulate the Down syndrome genome safely and effectively utilizing those things provided, with our gratitude, by our Creator.