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What does TNI stand for?
TNI stands for the “manipulation of gene expression by Targeted Nutritional Intervention,” a description coined by W. James Croom, Phd. NCSU, research scientist and team member.
Is it possible to regulate proteins and enzymes through targeted supplements?
Yes. Peer Reviewed, published trials prove that gene expression can be manipulated with nutrients and natural substances.
Who developed Targeted Nutritional Intervention?
A team of this country’s top research scientists put the theory of TNI in 1993. It is still researched by scientists today.
Is this a cure for DS?
No, it is a way to safely manage our children’s unique biochemical needs to enable them to reach their full potential as healthy, active, able individuals.
Do all people with DS need this?
All people with DS have altered biochemistry due to gene over expression. Just as a child with a normal genome requires a healthy diet full of appropriate nutrients for their needs, so do people with DS.
Have any studies been completed?
Over the years each nutrient has been studied numerous times and published in peer reviewed journals. There have been two third-party trials. One was completed in 2001 by Mathias Gelb and published in the German Journal of Pediatrics. A second trial followed shortly after authored by N. Miguid at the University of Cairo, Egypt. See research section For copies.
What were the results?
Blood tests, growth parameters, immune response and cognitive function tests demonstrated that TNI is effective according to trials.
Did the researchers share data during the trial periods?
No. They were complete strangers unaware that another trial was being conducted.
Were the researchers associated with the TNI team or International Nutrition?
No, these were independent studies by unbiased reporters.
How does TNI work?
The human genome relies on foods to function, not drugs. Nature has thankfully provided numerous substances that, when provided in the correct doses, from appropriate sources, can inhibit or down regulate over expressed genes, These have been studied both in vitro and in vivo. The genes mapped to the DS critical region of the additional 21st chromosome are actively adding their product (proteins, enzymes, etc.) to the patients cells causing a disruption of a large portion of the genome. These genes result in the phenotypic features (physical and neurological) of Down syndrome. If these genes were inactive, as are those on the rest of the additional chromosome, your child would not have Down syndrome. It is the active genes that produce the anomalies associated with DS.
TNI consists of diet and nutrients evidenced by scientific studies to be well suited to the unique nutritional needs of persons with a Down syndrome. Let’s look at just one example.
DYRK1a – this gene is a dual kinase. It is active in DS and therefore hyperphosforlates proteins that are not even located on C21. It is the job of DYRK1a to phosphorlate proteins, but when too much is present, the proteins are damaged. This causes numerous proteins to malfunction and in turn, everything that utilizes these hyperphosforlated proteins is disrupted. This greatly contributes to cognitive delay and the development of Alzheimer’s pathology. EGCG, a catichin found in green tea and some fruits and vegetables, is a known DYRK1a inhibitor. This inhibitor has been studied in the DS mouse model and in human beings with Down syndrome. All studies were very successful.
EGCG also inhibits several other genes that are over expressed in Down syndrome. However, in using EGCG caution must be taken to dose it only as high as necessary to inhibit these genes. After careful review of Blood profiles, including liver enzymes, folate, T Cells and iron in DS.
Is TNI harmful?
Dietitians and physicians have been recommending specific dietary management for individuals for centuries. Targeted Nutritional Intervention has been in use worldwide for 30 years. There have been no reports of serious side effects. This is not a drug regimine. It only contains natural substances in amounts necessary to produce the desired effect without causing harm. There are thousands of patients worldwide who have been on TNI for the entire 30 years, long term use is not harmful. The National Institutes of Health(NIH), the European Food Safety Authority(EFSA), and the Expert Group on Vitamins and Minerals(EVM) – an independent expert advisory committee convened by the Medicines and Healthcare products Regulatory Agency(MHRA) all produce reference guides on safe intake for vitamins and minerals listing levels that could cause harm or side effect as Upper Tolerable Limits(UTL) or Safe Upper Levels(SULs). TNI supplement levels are well below these levels. It is very safe.
Because it does alter your child biochemistry, it is important to slowly introduce it. Your child will need time to adjust.
What goes into the protocol.
Nutrients, plant polyphenols, minerals, amino acids, and rarely herbs make up portions of the protocol. All have hundreds of studies showing their impacts to biochemistry. Ingredients are carefully chosen and cross referenced with other genes to ensure the desired benefit could be reality.
What safety measures are taken during development?
Nutrivene products are the basis of TNI. They are produced with pharmaceutical grade ingredients in an FDA certified compounding pharmacy. The manufacturing process is tedious, and they are continually tested for contaminants and heavy metals at every stage. This insures that they are safe and effective for the unique biochemistry.