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RESEARCH,
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Recent Research Articles
Suggested Supplements Kaempferol - Page 9
Microglial phenotype in DS
Trisomy 21 produces:
• Early microglial hypertrophy, shortened processes, rod-like forms, and elevated Iba1, CD68 and Lamp1
• …
Suggested Supplements Lycopene- Page 8
The most DS-specific target: RCAN1
RCAN1 (also called DSCR1) sits in the Down syndrome critical region on chromosome 21. Extra copy number raises RCAN1 protein, which:
• increases mitochondrial and ce…
Suggested Supplements Hesperidin - Page 6
Pathways and genes most likely to be affected
1. APP processing and amyloid pathology
People with DS carry three copies of APP and develop Alzheimer-type plaques decades earlier than the general population. In APP/PS1 and…
Suggested Supplements Luteolin/Rutin -Page 5
Luteolin (often misspelled Leuteolin) and rutin do not directly silence or reduce the extra copy of chromosome 21 genes. They act downstream on the consequences of that overexpression—especially neuroinflammation, oxidative stress, APP/Aβ-related pat…
Suggested Supplements Apigenin - Page 4
Apigenin is a multi-target dietary flavonoid with preclinical support as a candidate therapy for Down syndrome (DS/trisomy 21), acting on CBS overexpression plus several other Hsa21-linked and secondary pathways that drive oxid…
Suggested Supplements LongVida Curcumin -Page 3
1. Why formulation is the first scientific point
Unformulated curcumin has oral bioavailability well under 1%. It is rapidly glucuronidated and sulfated in intestine and liver; free parent curcumin in plasma is often undetectable. Most in-vitro ta…