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Research
Research and writings related to Trisomy 21 and TNISuggested Supplements Kaempferia Black Ginger - 9
Suggested Supplements Lycopene- Page 8
The most DS-specific target: RCAN1
RCAN1 (also called DSCR1) sits in the Down syndrome critical region on chromosome 21. Extra copy number raises RCAN1 protein, which:
• increases mitochondrial and ce…
Suggested Supplements Hesperidin - Page 6
Pathways and genes most likely to be affected
1. APP processing and amyloid pathology
People with DS carry three copies of APP and develop Alzheimer-type plaques decades earlier than the general population. In APP/PS1 and…
Suggested Supplements Luteolin/Rutin -Page 5
Luteolin (often misspelled Leuteolin) and rutin do not directly silence or reduce the extra copy of chromosome 21 genes. They act downstream on the consequences of that overexpression—especially neuroinflammation, oxidative stress, APP/Aβ-related pat…
Suggested Supplements Apigenin - Page 4
Apigenin is a multi-target dietary flavonoid with preclinical support as a candidate therapy for Down syndrome (DS/trisomy 21), acting on CBS overexpression plus several other Hsa21-linked and secondary pathways that drive oxid…
Suggested Supplements LongVida Curcumin -Page 3
1. Why formulation is the first scientific point
Unformulated curcumin has oral bioavailability well under 1%. It is rapidly glucuronidated and sulfated in intestine and liver; free parent curcumin in plasma is often undetectable. Most in-vitro ta…
Suggested Supplements Polyphenol Formula -Page 2
Gene-targeted rationale for this Polyphenol Support mix (HSA21 overexpression + downstream pathways). This is the mechanistic story used in TNI; human efficacy remains mixed (small adult EGCG trials suggested cognitive signals; a pediatric EGCG RCT d…
Suggested Nutritional - Multi Formula Page 1
We suggest several products that, in accordance with your healthcare providers guidelines, have proven very beneficial in caring for your loved one with Down syndrome.
Nutrivene D Daily Supplement
Trisomy 21 overexpresses genes including SOD1, …
Urolithin A - DYRK1A Inhibitor Rationale
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WHY WE MUST DO A BETTER JOB OF INHIBITING DYRK1a.
DYRK1A (Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A) is a highly dosage-sensitive gene located on human chromosome 21q22.13, within the Down syndrome critical region. Due to the triplication of chromosome 21 in Down syndrome (DS), D…
Down Syndrome is Preclinical Alzheimer’s: Difficult truths, but hope abounds
Meet Healthcare Practitioners
Trisomy 21 Research Foundation work only with those practitioners with the best training, expertise and knowledge of Down Syndrome biochemistry. They are not employees of the Foundation, but healthcare professionals who h…
Peer Reviewed Studies Re: COVID Vaccine Safety
1000 Peer Reviewed …
FOR PARENT LESSONS CLICK “BASICS”
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Join the Discussion on MeWe or Facebook
Download the MeWe app or go to MeWe.com and open a free account. Then join Targeted Nutritional Intervention. We are leaving Facebook due to censorship and intrusive behaviors. We are an American Foundation and must be able to express ourselves under…
Autophagy in Down Syndrome
By Gabi Giacomin, Dr. of Naturopathic Medicine
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This Site is Confined to Research and Does Not Give Medical Advice
Trisomy 21 Research Foundation cannot provide medical advice. All articles, regardless who posts them ,have been written and approved upon the advice of our physicians and Healthcare providers.
Please refer to the…
Kunal Recovers from Regression
By Dr. Gabi Giacomin
KUNAL MAKES REGRESSION RECOVERY IN 8 WEEKS USING TNI, NATUROPATHY + SUPPORT
Its bittersweet adding another regression recovery story to my website. You can’t imagine how excited and relieved these parents are when their chil…
A Story of Regression in Down Syndrome and it’s Happy Ending
By Julia Sheppard
I’m going to share something personal and painful with you in hopes that it spares you that same pain. The past two years have been a nightmare for me and my family. We almost lost our precious Heather to something we still don’t…
1000 Peer Reviewed, published studies-vaccines unsafe
https://www.saveusnow.org.uk/covid-vaccine-scientific-proof-lethal/…
Protected: Vaccines Do Cause Neurological Disorders
There is no excerpt because this is a protected post.
Parents Taking Action
PARENTS TAKING ACTION
Subtitled Putting things into New Perspectives
By: Petra Anic, Phd, Physiology
Expecting and finally having
When Science and Belief Meet
When Science and Belief Meet
Over the weekend, I read parts of a book that had a profound impact on my own thinking. One point I think I have made very clear over the years is that, unlike many others who have devo…
Protected: 1200 Studies that Refute Vaccine Claims
There is no excerpt because this is a protected post.
What We Have Learned From Our Children
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Does Science Provide Evidence for Prayer?
MAY 17 2019 – THIS IS NOT A LESSON. It is just an observation but, it is confirmed by science. Often on this group and the others, we see threads concerning prayer. Should we be doing this in light of the various religions represented here? The answe…
The Role of Two Proteins, Beta CTF and Tau, in the Development of Alzheimer’s
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Leukemia and Down Syndrome
NOVEMBER 19/2018 LEUKEMIA AND DOWN SYNDROME Most citations used are taken from the NLM database and are in the public domain. Besides open heart surgery, I know first hand that the greatest fear we, as parents of children with DS live with, is the threat of Leukemia....
Scientific Advisory Committee
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Protected: DS Immune System Differences, vaccines
There is no excerpt because this is a protected post.