Suggested Supplements Kaempferia Black Ginger - 9

by | Sep 28, 2026 | Research

Rationale for the Use of Kaempferia parviflora (Black Ginger) as a Neuroprotective Anti-Inflammatory Agent Targeting Microglial Hyperactivity 1. Introduction and Clinical Need Chronic neuroinflammation driven by microglial hyperactivity is a primary pathophysiological...

Help for Alzheimer’s Patients

by | Sep 27, 2026 | Rationales, Uncategorized

Trisomy 21 Research Protocol for AD Very long post on the rational for the prevention of AD. This is NOT specific to DS but works in advanced AD in non DS patients as well. Note, not all substances utilized in TNI for DS are covered here. The science is so amazing....

Suggested Supplements Lycopene- Page 8

by | Sep 27, 2026 | Research

The most DS-specific target: RCAN1 RCAN1 (also called DSCR1) sits in the Down syndrome critical region on chromosome 21. Extra copy number raises RCAN1 protein, which: •  increases mitochondrial and cellular ROS, •  activates NF-κB, •  induces the apoptosis adaptor...

Suggested Supplements Hesperidin - Page 6

by | Sep 27, 2026 | Research

Pathways and genes most likely to be affected 1. APP processing and amyloid pathology People with DS carry three copies of APP and develop Alzheimer-type plaques decades earlier than the general population. In APP/PS1 and 5xFAD mice, hesperidin. •  reduces Aβ...