Urolithin A - DYRK1A Inhibitor Rationale

by | Sep 27, 2026 | Research

1. Urolithin A The Cellular Target: DYRK1A is over expressed in DS. This gene is both developmental and functional. This means the disruption present in fetal development continues during the entire lifetime. Heretofore, we have had few options with regard to...

WHY WE MUST DO A BETTER JOB OF INHIBITING DYRK1a.

by | Sep 27, 2026 | Research

DYRK1A (Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A) is a highly dosage-sensitive gene located on human chromosome 21q22.13, within the Down syndrome critical region. Due to the triplication of chromosome 21 in Down syndrome (DS), DYRK1A is...

Meet Healthcare Practitioners

by | Jul 17, 2023 | Research, Uncategorized

Trisomy 21 Research Foundation refers only to those practitioners with the best training, expertise and knowledge of Down Syndrome biochemistry. They are not employees of the Foundation, but healthcare professionals who have provided documentation that they have an...

Peer Reviewed Studies Re: COVID Vaccine Safety

by | Mar 1, 2023 | Research

Peer Reviewed Studies Questioning Covid-19 Vaccine Safety Peer Reviewed Medical Papers Submitted To Various Medical Journals, Evidencing A Multitude Of Adverse Events In Covid-19 Vaccine Recipients. . In-depth evaluation of a case of presumed myocarditis after the...